Identification of key amino acid residues required for horseshoe bat angiotensin-I converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus.
Identifieur interne : 002526 ( Main/Exploration ); précédent : 002525; suivant : 002527Identification of key amino acid residues required for horseshoe bat angiotensin-I converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus.
Auteurs : Meng Yu [Australie] ; Mary Tachedjian ; Gary Crameri ; Zhengli Shi ; Lin-Fa WangSource :
- The Journal of general virology [ 1465-2099 ] ; 2010.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Peptidyl-Dipeptidase A.
- métabolisme : Peptidyl-Dipeptidase A.
- physiologie : Virus du SRAS.
- Animaux, Chiroptera, Données de séquences moléculaires, Peptidyl-Dipeptidase A, Pénétration virale, Récepteurs de surface cellulaire, Spécificité d'espèce, Séquence d'acides aminés.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Peptidyl-Dipeptidase A.
- chemical , genetics : Peptidyl-Dipeptidase A.
- chemical , metabolism : Peptidyl-Dipeptidase A.
- physiology : SARS Virus.
- Amino Acid Sequence, Animals, Chiroptera, Molecular Sequence Data, Receptors, Cell Surface, Species Specificity, Virus Internalization.
Abstract
Angiotensin-I converting enzyme 2 (ACE2) is the receptor for severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV). A previous study indicated that ACE2 from a horseshoe bat, the host of a highly related SARS-like coronavirus, could not function as a receptor for SARS-CoV. Here, we demonstrate that a 3 aa change from SHE (aa 40-42) to FYQ was sufficient to convert the bat ACE2 into a fully functional receptor for SARS-CoV. We further demonstrate that an ACE2 molecule from a fruit bat, which contains the FYQ motif, was able to support SARS-CoV infection, indicating a potentially much wider host range for SARS-CoV-related viruses among different bat populations.
DOI: 10.1099/vir.0.020172-0
PubMed: 20335495
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001729
- to stream PubMed, to step Curation: 001729
- to stream PubMed, to step Checkpoint: 001657
- to stream Ncbi, to step Merge: 002100
- to stream Ncbi, to step Curation: 002100
- to stream Ncbi, to step Checkpoint: 002100
- to stream Main, to step Merge: 002561
- to stream Main, to step Curation: 002526
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of key amino acid residues required for horseshoe bat angiotensin-I converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus.</title><author><name sortKey="Yu, Meng" sort="Yu, Meng" uniqKey="Yu M" first="Meng" last="Yu">Meng Yu</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220</wicri:regionArea><wicri:noRegion>Victoria 3220</wicri:noRegion></affiliation></author><author><name sortKey="Tachedjian, Mary" sort="Tachedjian, Mary" uniqKey="Tachedjian M" first="Mary" last="Tachedjian">Mary Tachedjian</name></author><author><name sortKey="Crameri, Gary" sort="Crameri, Gary" uniqKey="Crameri G" first="Gary" last="Crameri">Gary Crameri</name></author><author><name sortKey="Shi, Zhengli" sort="Shi, Zhengli" uniqKey="Shi Z" first="Zhengli" last="Shi">Zhengli Shi</name></author><author><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20335495</idno><idno type="pmid">20335495</idno><idno type="doi">10.1099/vir.0.020172-0</idno><idno type="wicri:Area/PubMed/Corpus">001729</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001729</idno><idno type="wicri:Area/PubMed/Curation">001729</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001729</idno><idno type="wicri:Area/PubMed/Checkpoint">001657</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001657</idno><idno type="wicri:Area/Ncbi/Merge">002100</idno><idno type="wicri:Area/Ncbi/Curation">002100</idno><idno type="wicri:Area/Ncbi/Checkpoint">002100</idno><idno type="wicri:Area/Main/Merge">002561</idno><idno type="wicri:Area/Main/Curation">002526</idno><idno type="wicri:Area/Main/Exploration">002526</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Identification of key amino acid residues required for horseshoe bat angiotensin-I converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus.</title><author><name sortKey="Yu, Meng" sort="Yu, Meng" uniqKey="Yu M" first="Meng" last="Yu">Meng Yu</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220</wicri:regionArea><wicri:noRegion>Victoria 3220</wicri:noRegion></affiliation></author><author><name sortKey="Tachedjian, Mary" sort="Tachedjian, Mary" uniqKey="Tachedjian M" first="Mary" last="Tachedjian">Mary Tachedjian</name></author><author><name sortKey="Crameri, Gary" sort="Crameri, Gary" uniqKey="Crameri G" first="Gary" last="Crameri">Gary Crameri</name></author><author><name sortKey="Shi, Zhengli" sort="Shi, Zhengli" uniqKey="Shi Z" first="Zhengli" last="Shi">Zhengli Shi</name></author><author><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name></author></analytic><series><title level="j">The Journal of general virology</title><idno type="eISSN">1465-2099</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Chiroptera</term><term>Molecular Sequence Data</term><term>Peptidyl-Dipeptidase A (chemistry)</term><term>Peptidyl-Dipeptidase A (genetics)</term><term>Peptidyl-Dipeptidase A (metabolism)</term><term>Receptors, Cell Surface</term><term>SARS Virus (physiology)</term><term>Species Specificity</term><term>Virus Internalization</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chiroptera</term><term>Données de séquences moléculaires</term><term>Peptidyl-Dipeptidase A ()</term><term>Peptidyl-Dipeptidase A (génétique)</term><term>Peptidyl-Dipeptidase A (métabolisme)</term><term>Pénétration virale</term><term>Récepteurs de surface cellulaire</term><term>Spécificité d'espèce</term><term>Séquence d'acides aminés</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Chiroptera</term><term>Molecular Sequence Data</term><term>Receptors, Cell Surface</term><term>Species Specificity</term><term>Virus Internalization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Chiroptera</term><term>Données de séquences moléculaires</term><term>Peptidyl-Dipeptidase A</term><term>Pénétration virale</term><term>Récepteurs de surface cellulaire</term><term>Spécificité d'espèce</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Angiotensin-I converting enzyme 2 (ACE2) is the receptor for severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV). A previous study indicated that ACE2 from a horseshoe bat, the host of a highly related SARS-like coronavirus, could not function as a receptor for SARS-CoV. Here, we demonstrate that a 3 aa change from SHE (aa 40-42) to FYQ was sufficient to convert the bat ACE2 into a fully functional receptor for SARS-CoV. We further demonstrate that an ACE2 molecule from a fruit bat, which contains the FYQ motif, was able to support SARS-CoV infection, indicating a potentially much wider host range for SARS-CoV-related viruses among different bat populations.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Crameri, Gary" sort="Crameri, Gary" uniqKey="Crameri G" first="Gary" last="Crameri">Gary Crameri</name><name sortKey="Shi, Zhengli" sort="Shi, Zhengli" uniqKey="Shi Z" first="Zhengli" last="Shi">Zhengli Shi</name><name sortKey="Tachedjian, Mary" sort="Tachedjian, Mary" uniqKey="Tachedjian M" first="Mary" last="Tachedjian">Mary Tachedjian</name><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name></noCountry><country name="Australie"><noRegion><name sortKey="Yu, Meng" sort="Yu, Meng" uniqKey="Yu M" first="Meng" last="Yu">Meng Yu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002526 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002526 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:20335495
|texte= Identification of key amino acid residues required for horseshoe bat angiotensin-I converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20335495" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |